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Beilstein J. Org. Chem. 2022, 18, 1607–1616, doi:10.3762/bjoc.18.171
Graphical Abstract
Scheme 1: The diastereoselective synthesis of spirooxindoles through MCRs.
Figure 1: Bioactive Spirooxindole-pyrrolothiazoles.
Scheme 2: The synthesis of spirooxindolepyrrolothiazoles.
Scheme 3: Four-component reaction for the synthesis of compound 5.
Scheme 4: Proposed mechanism for the double [3 + 2] cycloadditions.
Scheme 5: The synthesis of compound 5a with ᴅ- and ʟ-cysteine.
Scheme 6: Two-step (process A) vs cascade (process B) synthesis of 5a. i) 1.0:1.15 of 1a/2, EtOH (0.05 M), 25...
Figure 2: Graphical representation of the green metrics (AE, AEf, CE, RME, OE and MP) analysis for processes ...
Figure 3: Graphical representation of the green metrics (PMI, E-factor, and SI) analysis for processes A and ...